To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more SERTRALINE (SER tra leen) is used to treat depression. It may also be used to treat obsessive compulsive disorder, panic disorder, post-trauma stress, premenstrual dysphoric disorder (PMDD) or social anxiety. Do not take your medicine more often than directed. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Do not stop taking this medicine suddenly except upon the advice of your doctor. They need to know if you have any of these conditions: -bleeding disorders -bipolar disorder or a family history of bipolar disorder -glaucoma -heart disease -high blood pressure -history of irregular heartbeat -history of low levels of calcium, magnesium, or potassium in the blood -if you often drink alcohol -liver disease -receiving electroconvulsive therapy -seizures -suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member -take medicines that treat or prevent blood clots -thyroid disease -an unusual or allergic reaction to sertraline, other medicines, foods, dyes, or preservatives -pregnant or trying to get pregnant -breast-feeding Take this medicine by mouth with a glass of water. Stopping this medicine too quickly may cause serious side effects or your condition may worsen. A special Med Guide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time. amoxicillin 1000 mg dosage Sertraline is used for a number of conditions, including major depressive disorder (MDD), obsessive–compulsive disorder (OCD), body dysmorphic disorder (BDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder (SAD). The comparative efficacy of sertraline and TCAs for melancholic depression has not been studied. A 1998 review suggested that, due to its pharmacology, sertraline may be more efficacious than other SSRIs and equal to TCAs for the treatment of melancholic depression. A meta-analysis of 12 new-generation antidepressants showed that sertraline and escitalopram are the best in terms of efficacy and acceptability in the acute-phase treatment of adults with unipolar MDD. Sertraline used for the treatment of depression in elderly (older than 60) patients was superior to placebo and comparable to another SSRI fluoxetine, and TCAs amitriptyline, nortriptyline (Pamelor) and imipramine. Sertraline had much lower rates of adverse effects than these TCAs, with the exception of nausea, which occurred more frequently with sertraline. In addition, sertraline appeared to be more effective than fluoxetine or nortriptyline in the older-than-70 subgroup. placebo in elderly patients showed a statistically significant (that is, unlikely to occur by chance), but clinically very modest improvement in depression and no improvement in quality of life. A meta-analysis on SSRIs and SNRIs that look at partial response (defined as at least a 50% reduction in depression score from baseline) found that sertraline, paroxetine and duloxetine were better than placebo. 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