Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine disadvantages gov Plaquenil maintenance dosage Does plaquenil cause weight gain The more common side effects that can occur with hydroxychloroquine include headache. dizziness. diarrhea. stomach cramps. vomiting. RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Aug 14, 2017 Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Plaquenil hydroxychloroquine side effects Plaquenil Hydroxychloroquine - Side Effects, Dosage., Common and Rare Side Effects for Plaquenil Oral Plaquenil immunocompromised Common side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss. Hydroxychloroquine Plaquenil, Plaquenil Sulfate, Quineprox. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Plaquenil Side Effects on Your Eyes and Vision. Hydroxychloroquine side effects may range from mild to severe, although some side effects may go away with time. Some of the most common side effects of hydroxychloroquine include 3, 4 loss of appetite. diarrhea. headache. nausea. vomiting. stomach pain. shakiness. skin rash. More serious hydroxychloroquine side effects include 3, 4 Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Upsides. Plaquenil hydroxychloroquine has been shown to improve physical function in up to 80% of patients with rheumatoid arthritis. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia.