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Celecoxib helps prevent the inflammation and pain caused by arthritis, acute pain, and dysmenorrhea, by decreasing an enzyme that helps make prostaglandins, which cause inflammation, swelling, and pain. According to the Centers for Disease Control and Prevention (CDC), 52.5 million adults, or just over one in five adults, in the U. Usually taken once every 24 hours, celecoxib is easy for patients to take; it is a member of the Cox-II inhibitor drug class, which was originally thought to be less likely to interfere with treatment for heart disease and also less likely to cause stomach bleeding. In recent years, the Cox-II drugs, including celecoxib, have a boxed warning, which states that non-steroidal anti-inflammatory drugs (NSAIDS), including celecoxib, are associated with an increased risk of serious (and potentially fatal) adverse cardiovascular thrombotic events, including myocardial infarction (heart attack), and stroke. All NSAIDS also may increase the risk of serious gastrointestinal ulceration, bleeding, and perforation (may be fatal). Common side effects include nausea, dizziness, diarrhea, cough, and water retention in extremities. In fact, in 2010, the Federal Trade Commission published a report, Pay to Delay, which describes the way some drug companies stall the release of new generics by compensating the generic company after it agrees to delay the release of their generic drug product. Please note: This article was published more than one year ago. The facts and conclusions presented may have since changed and may no longer be accurate. Questions about personal health should always be referred to a physician or other health care professional. FRIDAY, April 15, 2005 (Health Day News) -- In the post-Bextra, post-Vioxx age, how can arthritis patients get effective pain relief while protecting their hearts and stomachs from dangerous side effects? The answer may have arrived in a major new study, which used computer models to determine that a combination of two drugs -- a non-cox-2 pain reliever like Aleve, Advil or Motrin and a gastro-protective medicine like Prilosec or Nexium -- may be the best solution for a majority of arthritis patients. In fact, it may have always been the best solution, some experts say."For years I've been advocating a 'back to the future' combination of these two old and safe drugs," said Dr. Mark Fendrick, a long-time expert on these issues and a professor of internal medicine at the University of Michigan, Ann Arbor. Although not involved in the current study, Fendrick agreed that, for the vast majority of patients, a traditional non-steroidal anti-inflammatory drug (NSAID) plus one of the newer generation of acid-reducers, called proton pump inhibitors (PPIs), is the safest, most effective way of easing joint pain while sparing the heart and stomach. 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