Chloroquine dosing for lupus retina

Discussion in 'North West Pharmacy Canada' started by Basile333, 12-Mar-2020.

  1. paul_ryazanov Well-Known Member

    Chloroquine dosing for lupus retina


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

    Chloroquine methemoglobin Symptoms of eye damage from plaquenil

    Apr 02, 2019 This represents a total dose of 2.5 g chloroquine phosphate or 1.5 g base in three days. The dosage for adults of low body weight and for infants and children should be determined as follows First dose 10 mg base per kg but not exceeding a single dose of 600 mg base. Apr 20, 2011 Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Mar 15, 2019 The first reports of retinal toxicity attributed to chloroquine appeared during the late 1950s. In 1958, Cambiaggi first described the classic retinal pigment changes in a patient receiving chloroquine for systemic lupus erythematous SLE.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Chloroquine dosing for lupus retina

    Chloroquine Dosage Guide with Precautions -, New Plaquenil Guidelines

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  4. An 81-yearold Caucasian woman with a history of rheumatoid arthritis is referred for chronically decreased vision. She took an unknown dose of chloroquine for 17 years and discontinued the medication 25 years prior to her visit. She currently takes leflunomide Arava, Sanofi, Bridgewater, NJ for rheumatoid arthritis.

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    Detailed Hydroxychloroquine dosage information for adults and children. Includes dosages for Rheumatoid Arthritis, Systemic Lupus Erythematosus, Malaria Prophylaxis and more; plus renal, liver and dialysis adjustments. For treatment of acute attacks of malaria in adults, one dose is usually taken right away, followed by half the dose 6 to 8 hours later and then half the dose once a day for the next 2 days. For prevention and treatment of malaria in infants and children, the amount of chloroquine phosphate is based on the child's weight. Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy Retinal toxicity from chloroquine CQ and its analogue, hydroxychloroquine HCQ, has been recognized for many years. Chloroquine toxicity remains a problem in many parts of the world, but is seen less frequently in the United States where the drug largely has been replaced by HCQ.

     
  5. shurikanet New Member

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. PATIENT FACT SHEET Hydroxychloroquine Plaquenil Hydroxychloroquine Oral Route Proper Use - Mayo Clinic Plaquenil.long do I have to wait? DailyStrength
     
  6. nastradamus Moderator

    Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Pharmacokinetics and Metabolism of the Antimalarial. Clinical Pharmacokinetics of Antimalarial Drugs SpringerLink Chloroquine - Wikipedia
     
  7. andrews New Member

    Plaquenil Side Effects on Your Eyes and Vision If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage.

    Plaquenil Risk Calculators