To date, it was assumed that chloroquine increases the sensitivity of cancer cells to chemotherapy by means of a direct effect on the cancer cells. However, a recent study has demonstrated that chloroquine also normalizes the abnormal blood vessels in tumors. Side effects discontinuing plaquenil Chloroquine phosphate fowlr Hydroxychloroquine treatment for lyme disease Plaquenil eyes hurt Jul 15, 2014 Autophagy and cancer. A large body of evidence suggests that the relationship between autophagy and cancer is complex.42, 43 On the one hand, autophagy appears to inhibit malignant transformation, reflecting its capability to limit the accumulation of potentially oncogenic entities like depolarized mitochondria which overproduce potentially genotoxic reactive oxygen species, ROS. Chloroquine CQ is a well known, well tolerated medication that has been used for many years traditionally for arthritis, lupus, and malaria. It has anti-inflammatory properties but is often the drug of choice for arthritis and malaria due to its few side effects. Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Maycotte P1, Aryal S, Cummings CT, Thorburn J, Morgan MJ, Thorburn A. Chloroquine CQ is a 4-aminoquinoline. The anti-cancer effect of the antimalarial agent chloroquine when combined with conventional chemotherapy has been well documented in experimental animal models. This blood vessel normalization results in an increased barrier function on the one hand, and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy. Chloroquine and breast cancer Chloroquine sensitizes breast cancer cells to chemotherapy., A Phase 2 Randomized, Double-blind Trial Evaluating the. Using pei vs chloroquine transfectionSide effects of chloroquine on eyeHydroxychloroquine and kidneyNew plaquenil dosing guidelinesDoes famotidine interfere with plaquenil Indeed, current clinical trials are trying to use chloroquine or hydroxychloroquine, alone or in combination with other drugs to inhibit autophagy during breast cancer therapy since chemotherapy and radiation, regimens that are used to treat breast cancer, are known to induce autophagy in cancer cells. Chloroquine & Hydroxychloroquine supporting chemo.. The Chloroquine Story in Cancer Continues In the Pipeline. Chloroquine - FDA prescribing information, side effects and uses. Chloroquine CQ exerts anti-breast cancer through modulating microenvironment and inducing apoptosis. Zhang Y1, Cao Y2, Sun X3, Feng Y4, Du Y3, Liu F3, Yu C1, Jin F5. Author information 1Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China. Since chloroquine is an 'old' drug, repurposing it to help breast cancer patients should also be very cost effective." Hydroxychloroquine inhibits autophagy, a prosurvival process that breast cancer cells induce and that antiestrogens can stimulate. Whether interfering with this process can enhance breast cancer therapy remains unknown. It closely resembles stage IV human breast cancer both in its immunogenicity, growth and metastatic properties, making it an excellent animal model to evaluate the effects of drugs on breast tumor metastases as well as growth. Chloroquine diphosphate CQ has been widely used as a potent antimalarial and amebicidal drug.