B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. Plaquenil pulmonary Chloroquine phosphate tablets ip 250 mg uses A 48-year-old man with a long-standing history of systemic lupus erythematosus presented with a three-month history of mottled blue-grey hyperpigmentation on his face and on areas of previous bruising on his arms and legs Figure 11. There was no involvement of the mucous membrane or nails. His An elderly woman presented with 6 months history of skin coloured to erythematous papules in annular pattern over extremities, upper back and neck. The patient was diagnosed with granuloma annulare GA and started on hydroxychloroquine HCQ 300 mg daily. After 4 months of treatment, she developed bluish grey pigmentation within the plaques of GA with normal surrounding skin figure 1A,B. A differential diagnosis with hyperpigmentation caused by endocrine and metabolic disorders, the most closely-related disorders to drug-induced hyperpigmentation, and with hyperpigmentation of idiopathic origin, should be conducted. Drug-induced hyperpigmentation is a relatively frequent reason for consultation, especially in polypharmacy patients. B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Woman in grey hydroxychloroquine-induced hyperpigmentation Hydroxychloroquine-induced Hyperpigmentation of the Skin, Hydroxychloroquine induced cutaneous pigmentation a unique. Plaquenil side effects nauseaMethotrexate and plaquenil for rheumatoid arthritisPlaquenil and teeth lossQuinoric or plaquenil Background/Purpose To describe the clinical features and outcome of hydroxychloroquine-induced pigmentation in patients with systemic lupus erythematosus SLE. Method This was a retrospective, monocentric SLE clinic, Pitié-Salpêtrière, Paris study of SLE patients with pigmented lesions considered to be related to hydroxychloroquine HCQ. Talk Hydroxychloroquine-Induced Hyperpigmentation in.. Drug-Induced Hyperpigmentation Review and Case Series.. Skin pigmentation induced by meropenem and levofloxacin.. Hydroxychloroquine-related skin discoloration. Woman in grey Hydroxychloroquine-induced hyperpigmentation. clinical features and risk factors of hydroxychloroquine-induced pigmentation. We herein report a case of hydroxychloroquine‐induced hyperpigmentation. A 58‐year‐old woman had a 1‐year history of asymptomatic bluish‐gray hyperpigmentation on her neck, upper trunk and upper extremities. She was diagnosed with rheumatoid arthritis 4 years prior and treated with hydroxychloroquine 200 mg/day for 4 years. Nov 25, 2017 Hydroxychloroquine is a common cause of drug induced hyperpigmentation. Unlike the lighter blue-grey color in chrysiasis, hydroxychloroquine induced hyperpigmentation is deeper grey-blue, grey-brown or black color that looks like bruises. Oral mucosal hyperpigmentation is a characteristic clinical feature which distinguishes it from chrysiasis.