Chloroquine resistance to antimalarail drugs

Discussion in 'Cheap And Quality Drugs' started by moori, 19-Mar-2020.

  1. mrSERP New Member

    Chloroquine resistance to antimalarail drugs


    According to legend it was first brought to Europe by a Countess who had been treated with it in Peru in the 1600s. In 1820, two French chemists isolated quinine from the cinchona bark and quinine became a treatment of reference for intermittent fever throughout the world. Quinine remains an important and effective treatment for malaria today, despite sporadic observations of quinine resistance.

    Assay of chloroquine phosphate Plaquenil for granuloma annulare

    A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Call your doctor. Verapamil, a Ca 2+ channel blocker, has been found to restore both the chloroquine concentration ability and sensitivity to this drug. Recently, an altered chloroquine-transporter protein CG2 of the parasite has been related to chloroquine resistance, but other mechanisms of resistance also appear to be involved. It is unknown if P. malariae or P. ovale has developed resistance to any antimalarial drugs. P. knowlesi, a zoonotic monkey malaria that infects humans in forest fringe areas of Southeast Asia, is fully susceptible to chloroquine and other currently used drugs. Drug-resistant P. falciparum

    These compounds belonged to a new class of antimalarials, the four-amino quinolines. Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin (chloroquine) and Sontochin (3-methyl-chloroquine).

    Chloroquine resistance to antimalarail drugs

    The Origins of Antimalarial-Drug Resistance NEJM, Chloroquine - Wikipedia

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  7. Feb 09, 2018 In this video, I will explain into one of the main antimalarial drug, chloroquine. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive.

    • Antimalarial Drug Mechanism of Action What is Chloroquine..
    • Drug Resistance in the Malaria-Endemic World - CDC.
    • Antimalarial Drugs and Drug Resistance Saving Lives..

    The development of chloroquine resistance by malaria parasites is increasing at an alarming rate especially in the tropical countries where it is used extensively as an antimalarial drug 2. In the past years, the drug of choice has changed from chloroquine to artemisinin. Plasmodium Chloroquine Resistance and the Search for a Replacement Antimalarial Drug Thomas E. Wellems Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. The emergence of chloroquine resistance has been associated with a dramatic increase in malaria mortality among inhabitants of some endemic regions. The rationale for chemoprophylaxis is weakening as multiple-drug resistance develops against well-tolerated drugs.

     
  8. PerS Well-Known Member

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Compare Plaquenil vs Methotrexate - Hydroxychloroquine Oral Route Description and Brand Names - Mayo Clinic
     
  9. Alpha_Juno Moderator

    Hydroxychloroquine Advanced Patient Information - Hydroxychloroquine belongs to a group of medicines known as antimalarials. It works by preventing or treating malaria, a red blood cell infection transmitted by the bite of a mosquito. However, hydroxychloroquine is not used to treat severe or complicated malaria.

    Systemic Lupus Erythematosus SLE Treatment & Management.
     
  10. enzyncdep XenForo Moderator

    Chloroquine Oral Route Proper Use - Mayo Clinic Chloroquine works best when you take it on a regular schedule. For example, if you are taking it once a week to prevent malaria, it is best to take it on the same day of each week. Make sure that you do not miss any doses. If you have any questions about this, check with your doctor.

    Chloroquine C18H26ClN3 - PubChem