Sildenafil in children

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  1. Bitrain New Member

    Sildenafil in children


    There were 269 children included in this study: 47 with idiopathic pulmonary arterial hypertension, 53 with congenital heart disease, 135 with bronchopulmonary dysplasia, 24 with congenital diaphragmatic hernia, and 7 with other causes. Sildenafil was initial monotherapy in 84.8% and add-on therapy in 15.2%. Median follow-up time was 3.1 years (2 weeks-12.4 years). On follow-up, 99 (37%) remained on sildenafil or transitioned to tadalafil, 93 (35%) stopped sildenafil for improvement in PH, 54 (20%) died, and 20 (7%) were lost to follow-up. PH was most likely to improve in those with bronchopulmonary dysplasia, allowing for the discontinuation of sildenafil in 45%. Eighteen deaths were related to PH and 36 from other systemic causes. Two patients stopped sildenafil owing to airway spasm with desaturation. Please select whether you prefer to view the MDPI pages with a view tailored for mobile displays or to view the MDPI pages in the normal scrollable desktop version. This selection will be stored into your cookies and used automatically in next visits. You can also change the view style at any point from the main header when using the pages with your mobile device. Pulmonary arterial hypertension (PAH) management has been transformed in recent times with the advent of cheap and effective diagnostic tools and therapy. Sildenafil, a phosphodiesterase-V inhibitor, has been at the centre of this treatment, and its success in treating PAH has led to its widespread uptake in adult and paediatric pulmonary hypertension (PH), as a first line treatment choice. This might apply to persistent pulmonary hypertension of the newborn (PPHN) or bronchopulmonary dysplasia, as well as to more complex diseases, such as idiopathic pulmonary hypertension. Although recent data regarding long-term mortality and the repeal of Food and Drug Administration (FDA) approval has complicated the issue, Sildenafil continues to be the major treatment option for paediatric PH for patients in a variety of contexts, and this does not seem likely to change in the foreseeable future.

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    Aug 31, 2012. The FDA has cautioned against using sildenafil Revatio to treat pulmonary arterial hypertension in children younger than 17, after an. Click related term for sildenafil phosphodiesterase 5 inhibitors. › Treatment of male sexual. Pulmonary hypertension in children Management and prognosis. Medscape - Pulmonary hypertension, erectile dysfunction-specific dosing for Revatio, Viagra sildenafil, frequency-based adverse effects. AdultPediatric.

    Sildenafil is used to treat high blood pressure in the lungs (pulmonary hypertension). It works by relaxing and widening the blood vessels in your lungs which allows the blood to flow more easily. Decreasing high blood pressure in the lungs allows your heart and lungs to work better and improves your ability to exercise. This medication is not recommended for use in children. Discuss the risks and benefits of this medication with the doctor. Read the Patient Information Leaflet provided by your pharmacist before you start taking sildenafil and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Doctors are giving infants and babies the anti-impotence drug Viagra to save them from a life-threatening lung condition even though it has not been tested on children, a magazine said Tuesday. "Critics have expressed serious concern at the fact that no clinical trials have taken place for this use of the drug and at the wide variation in doses used," New Scientist magazine said in its online version. pharmaceutical giant Pfizer, has already been used to treat a small number of children with pulmonary hypertension in India, the United States, Canada and Britain with promising results. Although the drug is approved for the treatment of impotence, doctors have found that it helps babies suffering from PHT, which affects 28,000 children and 250,000 adults in the United States alone. The magazine said adults with PHT were already being enrolled in clinical trials of the drug. Studies on children could start in the next few months. A spokesman for Pfizer said the company was considering using the drug to treat PHT, but could not comment on any clinical trails."We are seriously looking into the use of Viagra for PHT," he told Reuters. Viagra was originally developed to treat angina by opening up blood vessels when doctors and patients discovered the impact it had on male sexual arousal. In babies with the problem a bypass vessel used for fetal circulation fails to close after birth, depriving the child of oxygen. PK Rajiv, of the Amrita Institute of Medical Sciences in Kochi, India, treated an 8-hour-old baby girl with the drug after other treatment failed."The child recovered in 48 hours and within a week two other newborns survived the same treatment," he told the magazine.

    Sildenafil in children

    Clinical Trials Update The Pediatric Sildenafil Trial Advances in., Sildenafil - UpToDate

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  5. Sildenafil for pulmonary hypertension. This leaflet is about the use of sildenafil for pulmonary hypertension. This leaflet has been written specifically about the use of this medicine in children.

    • Sildenafil for pulmonary hypertension Medicines for Children.
    • Revatio, Viagra sildenafil dosing, indications, interactions, adverse..
    • Frontiers Reported Sildenafil Side Effects in Pediatric Pulmonary..

    Abstract. Sildenafil is a phosphodiesterase 5 inhibitor widely used for the treatment of pulmonary hypertension in children. Despite limited available safety and. Sildenafil relaxes muscles of the blood vessels and increases blood flow to particular areas of the body. Sildenafil under the name Viagra is used to treat erectile dysfunction impotence in men. Comparison of steady-state concentrations in children with adults showed an overall decreased exposure in children, so that the 20–40 mg tid dosing of sildenafil in children provides an exposure comparable to 20 mg tid dosing in adults.

     
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