Tamoxifen aromatase inhibitor

Discussion in 'Canadian Pharmacy' started by Olcons, 01-Sep-2019.

  1. Skiler New Member

    Tamoxifen aromatase inhibitor


    The antiestrogen tamoxifen has potent activity against estrogen receptor–positive breast cancer, but two nonsteroidal aromatase inhibitors, letrozole and anastrozole, show considerable advantages over tamoxifen with respect to patient survival and tolerability. To determine the optimal way to use letrozole and tamoxifen, we studied their effects on a breast tumor xenograft model, MCF-7Ca, that is responsive to both antiestrogens and aromatase inhibitors. Female ovariectomized BALB/c athymic nude mice carrying xenograft tumors were treated daily subcutaneously with one of the following first-line therapies for varying durations: no drug (control), tamoxifen (100 μg/day) alone, letrozole (10 μg/day) alone, both drugs at the same time, or alternating 4-week courses of each drug (beginning with a course of tamoxifen or beginning with a course of letrozole). Tumor volumes and weights were estimated using linear mixed-effects models. The time to tumor doubling was calculated, and tumor weights in the treatment groups were compared, with adjustments for multiple comparisons being made with either Tukey’s or Dunnett’s procedure. Second-line therapies (with tamoxifen, letrozole, or fulvestrant) were initiated when tumors doubled in size under first-line therapies. The times for doubling of tumor volume were as follows: control, 3–4 weeks; tamoxifen alone, 16 weeks; tamoxifen alternating with letrozole, 17–18 weeks; tamoxifen plus letrozole, 18 weeks; letrozole alternating with tamoxifen, 22 weeks; letrozole alone, 34 weeks. First-line treatment with letrozole was superior to treatment with tamoxifen alone or with the two drugs combined (at week 16, both First-line letrozole therapy extends time for tumor progression in this model relative to the other treatment regimens tested. Tamoxifen, long considered the gold standard for treating estrogen-receptor (ER) positive, early-stage breast cancer, is known to increase the risk of thrombotic events (blood clots). This is of particular concern for women who have clotting disorders. Investigations have been ongoing to determine if aromatase inhibitors (AIs), also approved for treating postmenopausal women with ER-positive tumors, similarly increase a patient’s risk for thrombotic events. Data from various studies suggest that although AIs may increase the incidence of thrombotic events in cancer patients, the risk is not as great as it is with tamoxifen. Researchers in Edinburgh, Scotland, conducted an open, randomized, pharmacodynamic study to determine whether different AIs affected individual blood coagulation factors differently. They also wanted to find out how switching from an AI to tamoxifen might further affect blood coagulation. Investigators recruited 120 postmenopausal women with invasive ER breast cancer, described as “otherwise healthy,” and randomized them to receive 16 weeks of adjuvant therapy with either letrozole (Femara), anastrozole (Arimidex), or exemestane (Aromasin).

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    Aromatase inhibitors are an established adjuvant treatment for postmenopausal female breast cancer and have been shown to be more effective than tamoxifen in preventing recurrence. My oncologist prescribed five years of tamoxifen. These work by inhibiting the enzyme aromatase and blocking the body's production of. Aug. 2011. Toronto – Obwohl Aromatase-Inhibitoren Rezidive eines postmenopausalen Mammakarzinoms besser verhindern als Tamoxifen, konnte ein.

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    Tamoxifen aromatase inhibitor

    Aromatase inhibitors 'significantly reduce breast cancer deaths', Should I switch from tamoxifen to an aromatase inhibitor?

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    Switching from Tamoxifen to Aromatase Inhibitor Improves Survival in Early Breast Cancer. According to an article recently published in the. Aromatase inhibitors stop the production of estrogen in postmenopausal women. A number of studies have compared aromatase inhibitors with tamoxifen to see which type of medicine was. Тамоксифен — лекарственное средство для лечения рака молочной железыТамоксифен обладает смешанными свойствами антагониста и агониста эстрогенов, т.е. является частичным.

     
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