Plaquenil and thinning outer nuclear layer of retina

Discussion in 'Canadian Pharmacy Drugs Online' started by AVP, 01-Mar-2020.

  1. m_urka Guest

    Plaquenil and thinning outer nuclear layer of retina


    Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology.

    Plaquenil food interactions American academy of ophthalmology plaquenil screening guidelines Plaquenil dosage per weight Chloroquine cardiomyopathy beyond ocular adverse effects

    SD-OCT showed loss of the parafoveal inner/outer segment junction, thinning of the parafoveal outer nuclear layer, and a loss of the normal foveal depression, which is characteristic for hydroxychloroquine retinal toxicity Figure 3. While MS could affect different retinal layers, outer retinal layer changes following acute ON without a previous history of MS have been evaluated in only a few studies. In one study, the GCIPL layer was evaluated, and its thinning, which represents permanent shrinkage or loss of retinal ganglion cells, was observed at 1 month Kupersmith et al. 2016. Aug 08, 2018 This relative thinning of outer retinas was caused by a thinning of two specific portions of the outer retina the outer nuclear layer ONL and ellipsoid zone EZ.

    While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula.

    Plaquenil and thinning outer nuclear layer of retina

    Retina Today - Imaging in Hydroxychloroquine Toxicity., Photoreceptor outer nuclear layer thickness changes in optic.

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  5. The pathogenic effect of plaquenil is the induction of lysosomal dysfunction in photoreceptors and retinal pigment epithelium RPE cells. A lysosome is a membrane-bound organelle found in the cytoplasm of most cells and it contains hydrolytic enzymes that function in intracellular digestive processes.

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    Parafoveal thinning of the outer nuclear layer follows, before retinal pigment epithelium damage is visible. Careful screening with multiple tests can detect toxic damage before prominent loss of the outer nuclear layer. Thinning of the peripapillary retinal nerve fiber layer pRNFL and ganglion cell + inner plexiform layer GCIP, observed on optical coherence tomography OCT, are known to be accelerated in MS, even in the absence of optic neuritis, which is common in MS. Spectral-domain optical coherence tomography demonstrating advanced hydroxychloroquine retinopathy with parafoveal loss of the external limiting membrane, disruption of the outer ellipsoid zone, thinning of the outer nuclear layer and disruption to the underlying retinal pigment epithelial layer A.

     
  6. SashTS XenForo Moderator

    Plaquenil is also known as hydroxychloroquine, so the parent drug Chloroquine can be substituted. Discontinued Plaquenil.other options? Alternative" to plaquenil. ProHealth Fibromyalgia, ME. Alternatives to Hydroxychloroquine - Lupus - Inspire
     
  7. Jukebox Well-Known Member

    CHLOROQUINE PHOSPHATE TABLETS, USP 250 MG and 500 MG The dosage of chloroquine phosphate is often expressed in terms of equivalent chloroquine base. Each 250 mg tablet of chloroquine phosphate is equivalent to 150 mg base and each 500 mg tablet of chloroquine phosphate is equivalent to 300 mg base. In infants and children the dosage is preferably calculated by body weight.

    Chloroquine Phosphate Tablets - Chloroquine Phosphate Oral.
     
  8. Paulb Guest

    Top Ten Drugs That Cause Kidney Damage - EmpowHER Some of her info I would have to question. I have systemic lupus and I see the top rheumatologist in the country and he prescribes hydroxychloroquine Plaquenil for his lupus patients. This is pretty much a miracle drug for lupus patients. It helps with all the joint pains, fevers, keeps cholesterol down, and prevents kidney damage.

    Will you have Acute kidney failure with Plaquenil - eHealthMe