I am very underweight and do have chronic diarrhea, but gosh, this seems invasive as a first step in trying to figure out . Has anyone had chronic diarrhea/weight loss from Plaquenil? What does plaquenil do for sjogren& 39 Medication reaction to plaquenil I've been taking Plaquenil for one month 1 x 200 mg. I should have taken 2 x 200 mg but from the beginning I had diarrhea and stomach pain. If I want to increase the Plaquenil my complaints get worse. Reported are stomach pain, nausea, vomiting, and headache. These side effects can often be lessened by taking hydroxychloroquine with food. Hydroxychloroquine may also cause itching in some people. All medicines may have some side effects. Minor side effects such as nausea, occasional vomiting, or diarrhea usually do not require I had a terrible time with plaquenil when I first started it. Tremondous gas, diarrhea and dizziness. My rheumy had me cut the dose down to 1/4 a tablet and then slowly over a month add 1/4 a tablet at a time. If diarrhea came back I had to back off and wait a week to add it again. My rheumatologist nor the GI doctor have suggested alternate treatments to see if it could be the problem. I know it can be a temporary side effect for some, but I've been on it for a year. Plaquenil nausea diarrhea Plaquenil, diarrhea and weight loss? - Sjogren's World, Medicines for the Prevention of Malaria While Traveling. Chloroquine authophagy What are the side effects of Plaquenil? The most common side effects are diarrhea, nausea, vomiting, headache, dizziness, skin rash or black spots when you look at things. Most side effects will go away when your body gets used to the medicine. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Plaquenil and dizziness DailyStrength. Plaquenil and. diarrhea! rheumatoid. Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Rarely it can cause an upset stomach or diarrhea. Skin rash – Plaquenil can rarely cause a rash. Patients who experience this rare side effect should stop taking this medicine and contact their doctor. Headaches – Plaquenil can rarely cause a headache. Sun Sensitivity – Plaquenil can sometimes make the skin more sensitive to the sun. Nausea and diarrhea This can often can be combatted by taking Plaquenil with food or milk. If you experience stomach upset while taking generic hydroxychloroquine, ask your doctor about trying name-brand Plaquenil instead.