While the mechanism is poorly understood, pregnant women have a reduced immune response and therefore less effectively clear malaria infections. In addition, malaria parasites sequester and replicate in the placenta. Chloroquine dose for prophylaxis Medicare allowable ocular testing for chloroquine therapy Answer Pregnant women should avoid travel to malaria-endemic areas if possible. However, if travel cannot be avoided, measures to prevent mosquito bites, along with an effective chemoprophylaxis regimen, should be implemented. Chloroquine or hydroxychloroquine are considered safe to use in all trimesters of pregnancy. Plaquenil hydroxychloroquine is a good choice for people who have difficulty tolerating newer biologic medications. A generic form of Plaquenil hydroxychloroquine is available. chloroquine is generally safe to use during pregnancy and for children. You can take chloroquine with or without food. Chloroquine is also used for prophylaxis for pregnant women and non-immune individuals at risk. Dosage and administration. All dosages are described in terms of the base. Treatment. Oral administration. To avoid nausea and vomiting chloroquine should be administered after meals. Malaria infection during pregnancy can lead to miscarriage, premature delivery, low birth weight, congenital infection, and/or perinatal death. Pregnant women are three times more likely to develop severe disease than non-pregnant women acquiring infections from the same area. Use of chloroquine during pregnancy Chloroquine for Malaria in Pregnancy - Full Text View., Compare Plaquenil vs Chloroquine - Plaquenil and dementiaStomach pain from plaquenilPlaquenil and constipationPregnancy category hydroxychloroquine If you're pregnant or thinking about getting pregnant and want a healthy baby, then it's very important to avoid drug use during pregnancy. Illegal drugs such as marijuana, cocaine, and. Effects of Drugs & Alcohol During Pregnancy. WHO Model Prescribing Information Drugs Used in Parasitic.. The use of chloroquine during pregnancy.. The excretion of chloroquine and the major metabolite, desethylchloroquine, in breast milk was investigated in eleven lactating mothers following a single oral dose of chloroquine 600 mg base. The maximum daily dose of the drug that the infant can receive from breastfeeding was about 0.7% of the maternal start dose of the drug in malaria chemotherapy. It appears to be safe for use during pregnancy. It works against the asexual form of malaria inside the red blood cell. Chloroquine was discovered in 1934 by Hans Andersag. It is available as a generic medication. Chloroquine use in pregnancy has not been shown to cause a baby to be born early in any of the four studies that have investigated this. Studies have, however, shown that preterm birth is more common in pregnant women with malaria infection.