Regardless of the problem, we'd like to help you find what you're looking for. I've been taking Plaquenil 400 mg for nearly 6 mos. Plaquenil discoid lupus Effect of chloroquine injection on early pregnancy Can i take advil cold and sinus with hydroxychloroquine Plaquenil antibiotics are part of the fluoroquinolone antibiotics. Muscle weakness is a side effect. I would be very cautious! Quinolone antibiotics are chemotherapeutic and late side effects months to years later are common. Plaquenil and Weakness - from FDA reports Summary Weakness is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Enbrel, and have Osteoporosis. Muscular weakness is found among people who take Fluconazole and Plaquenil, especially for people who are female, 60+ old, have been taking the drugs for 6 - 12 months, also take medication Lisinopril, and have Antibiotic therapy. This review analyzes which people have Muscular weakness with Fluconazole and Plaquenil. But now I've been dealing with considerable muscle aching and pain/spasm in some new places - or at least places that haven't bothered me in quite awhile. I didn't seem to have any problems whatsoever with it initially, other than very short term and mild cramping/diarrhea. Plaquenil and muscle weakness Hydroxychloroquine and Colchicine Induced Myopathy The., Will you have Weakness with Plaquenil - eHealthMe Best time to take hydroxychloroquineChloroquine injection routeHydroxychloroquine tablets images About a month ago, I finally decided to start taking the Plaquenil. I took 100 mg daily for a week since I'm highly sensitive to new medications, with the goal of reaching 400 mg daily after three weeks. One of my most bothersome symptoms is muscle weakness and fatigue, and the Plaquenil seemed to exacerbate it dramatically. Plaquenil and muscle weakness Lupus Forums at The Lupus Site. Fluconazole and Plaquenil drug interaction Muscular weakness.. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells. Frequency not reported Skeletal muscle myopathy or neuromyopathy leading to progressive weakness and atrophy of proximal muscle groups, depression of tendon reflexes and abnormal nerve conduction studies. Myopathy may be reversible after therapy discontinuation, but recovery may take many months. Nervous system This medicine may cause muscle and nerve problems. Check with your doctor right away if you have muscle weakness, pain, or tenderness while using this medicine. Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors.