After 20 years I developed terrible back pain and sciatica. I originally started on Gabapentin in 2002 due to a back injury (torn disc L4 - L5) and now degenerative bone disease too. 4x a day (1200mg.) but for the first 2 weeks it was like being on acid... it was a fun ride but I told my doc and he laughed and then lowered my dose to 300md. I've been on Gabapentin for 13 years now and it hasn't caused me any long term problems so I'm guessing it's safe enough. An MRI showed significant arthritis, calcification and stenosis. although, my dose was just increased to that from 600mg. 3x a day (900mg.) and that took care of the melting walls and stuff. Average dose for plaquenil is 1 tablet daily Plaquenil 200mg dosage Gabapentin Moderate Caution is warranted with the coadministration of hydroxychloroquine and antiepileptic drugs, such as gabapentin. Hydroxychloroquine can lower the seizure threshold; therefore, the activity of antiepileptic drugs may be impaired with concomitant use. A study for a 53 year old woman who takes Leflunomide, Plaquenil, Gabapentin - from FDA reports Summary 3,102 females aged 53 ±5 who take the same drugs are studied. I am a little afraid at this point as I have always been a healthy inidividual. I have spent that last couple of years really going down hill. At least now there is a diagnosis and I will begin treatment starting tonight with the gabapentin. Doc indicates that it can take up to 2-3 months for the plaquenil to aid in reflief for the Lupus. Interactions between your selected drugs No results found - however, this does not necessarily mean no interactions exist. Other drugs that your selected drugs interact with Motrin (ibuprofen) interacts with more than 200 other drugs. I also have migraines and the Gabapentin has helped a lot in both areas, with minimal side effects. Is it safe to take gabapentin and plaquenil Is it safe to take plaquenil and gabapentin together - Answers, Leflunomide, Plaquenil, Gabapentin for a 53-year old woman. Plaquenil 400 mg bidCan plaquenil cause tiredness Plaquenil & Gabapentin I spoke to pharmacist today about interaction between Plaquenil & Gabapentin - after a 10 minute search I got an answer, so here goes Plaquenil reduces the potency of Gabapentin, which can be a problem when it's used as an anti-convulsant. Plaquenil & other drug interactions ? Lupus Forums at The Lupus Site. Plaquenil & Gabapentin - Lupus and Fibromyalgia" Lupus.. Stopping Gabapentin How to Stop Taking Gabapentin. Is It Safe To Take Tramadol & Gabapentin Together? Is it safe to take a tramadol and gabapentin together? Can anyone help? Answer. According to my research, these two drugs have a 'moderate. Since gabapentin works so well as an adjuvant, it is also frequently used in combination with drugs of abuse to intensify their effects, especially opioids. In July 2017, a report in Kaiser Health News detailed the dangers of recreational drug users taking high doses of gabapentin along with opioids, a practice called stacking. Interestingly. Gabapentin may interact with certain types of substances and cause negative side effects. For example, mixing alcohol and gabapentin can cause people to feel dizzy or tired. Despite the risk of bad side effects from using the drug, it can be more dangerous to stop using it. Gabapentin use can cause physical dependence. So, if you stop using it.