Hi Dr V, I am at a crossroad of considering to go back on Plaquenil . A year ago I proposed to go off Plaquenil after being on it for 22 years. Chloroquine and depression How many people taking hydroxychloroquine Hydroxychloroquine 200 mg discounts Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. It is now 6 weeks later, I've titrated up to 600mg. per day, and I am SEVERELY depressed, to the point I can't get out of bed some days. I am sicker mentally than I have been for 16 years, and it didn't start until I started the plaquenil. I'm so anxious, I'm agoraphobic and having anger attacks. I have never been agoraphobic in my life. If I had joint or muscle aches, I took care of it by resting, Aleve and ice. At my recent eye exam the doctor mentioned I had reached the plaquenil toxicity level and that my retina cells could die (which do not regenerate! My proposal was based on the fact that I had not had any major inflamation that completely shut me down or keep me from being active. What is the half life of plaquenil Plaquenil Hydroxychloroquine Sulfate, Hydroxychloroquine - Wikipedia Hydroxychloroquine aplastic anemiaMetoprolol and hydroxychloroquineChloroquine lysotrackerPlaquenil and alcoholU87 glioma chloroquine The mean time to peak plasma concentration was 1.83 hours. The mean plasma elimination half-life varied, depending on the post-administration period, as follows 5.9 hours at C max-10 hours, 26.1 hours at 10-48 hours and 299 hours at 48-504 hours. The parent compound and metabolites are widely distributed in the body and elimination is. Plaquenil 200mg Film-coated Tablets - Summary of Product.. PLAQUENIL Side Effects, Reviews by Patients -. Chloroquine - Wikipedia. I wonder if what you're noticing is really the change in dose. I say this because Plaquenil has a chemical half-life of 30-60 days you can confirm this on wiki or RX info on the drug--so it takes a LONG time to get out of your system.long for you to notice changes in days. With a half-life of 537 hours 22.4 days. In the same study, the plasma peak concentration was. 50.3 ng/mL reached in 3.74 hours with a half-life of 2963 hours 123.5 days. Urine hydroxychloroquine levels were still detectable after 3 months with approximately 10% of the dose excreted as the parent drug. The absorption half-life was approximately 3 to 4 hours and the terminal half-life ranged from 40 to 50 days. The long half-life can be attributed to extensive tissue uptake rather than through decreased excretion. Peak plasma levels of hydroxychloroquine were seen in about 3 to 4 hours.