Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil lyme herx Plaquenil sun pharmaceuticals Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Side Effects Stomach cramping, diarrhea, mild to severe headaches, dizziness, bloating, gas, loss of appetite and nausea. “Side Effects Diarrhea,gas,nausea and bloating. Big mistake.off Plaquenil and have been experiencing horrible symptoms of fatigue and pain. “Side Effects Rash on neck began on day 8. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine and stomach pain Stomach cramps from Plaquenil - what to do? Lupus Forums at., Hydroxychloroquine Uses, Dosage & Side Effects - Chloroquine cancer patientsAllergy to chloroquine which anti-malaria tablet should you take But stomach problems seem to be directly related to how sjogrens affects me anyway. I think it's ironic that the routine medication for it also can cause stomach issues. Nevertheless, I decided the stomach pain was more than I could live with and I really could not tell a significant difference in inflammation reduction when I was taking it. Plaquenil/Hydroxychloroquine and stomach problems?. Hydroxychloroquine Sulfate Abdominal Distension Reports.. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Hydroxychloroquine can cause an upset tum, it's a common side effect so it could be the longer you're taking it there's a build up effect. Trouble is you've other things coming up so it could be nervous tum, or even the two both making your tum particularly sensitive. I started taking Plaquenil 4 weeks ago for non specific autoimmune disease as indicated by ANA. Symptoms were low grade temperature off and on for a year, joint pain and fatigue. I have already felt some relief. Some nauseau at first but less problem with fever and joint pain. But, now I have started having stomach cramps and diarrhea. I understand these may go away. Is there anything I can. While these medications contain the same active ingredient, the preparation of generic hydroxychloroquine can sometimes cause stomach irritation. This sort of upset usually does not occur with commercial Plaquenil. Your doctor can ensure that you receive this version of the medication by writing “do not substitute” on your script.