Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Hydroxychloroquine cause bladder infections Plaquenil cataracts toxicity Will plaquenil help osteoarthritis Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species ROS related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. Targeted inhibition of RAF–MEK–ERK signaling induces autophagy through the LKB1–AMPK axis, creating a therapeutic vulnerability that can be exploited for treating patients with pancreatic. Chloroquine diphosphate, apoptosis and autophagy inhibitor CAS 50-63-5, with 98% purity. Water soluble compound. Join researchers using our high quality biochemicals. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Chloroquine and autophagy Chloroquine Indications, Side Effects, Warnings -, Protective autophagy elicited by RAF→MEK→ERK inhibition. Plaquenil fights cancer Herein, we report results of administration of rapamycin, a specific inhibitor of the mechanistic target of rapamycin mTOR signaling pathway, and chloroquine, a lysosomal inhibitor which reverses autophagy by accumulating in lysosomes, responsible for blocking autophagy in 20-month old VCPR155H/+ mice. Rapamycin and Chloroquine The In Vitro and In Vivo.. Chloroquine diphosphate, apoptosis and autophagy inhibitor.. Inhibition of autophagy with chloroquine is effective in.. Chloroquine in the Kidney, the Double-Edged Sword of Autophagy. The use of chloroquine in combination with other chemotherapeutic reagents may enhance cancer treatment 8, 29, but normal cells also use autophagy to maintain homeostasis, and inhibition of autophagy by chloroquine may sensitize not only cancer cells, but also normal organs to chemotherapy. Autophagy has recently been demonstrated as important for conferring resistance to chemotherapy, radiation therapy and immunotherapy. Compounds are now available that can reverse autophagy, including the antimalarial compounds chloroquine and hydroxychloroquine, as well as the antidepressant agent clomipramine. Autophagy is a homeostatic cellular recycling system that is responsible for degrading damaged or unnecessary cellular organelles and proteins. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the.