Spruance S, Overall J, Kern E, Krueger G, Pliam V, Miller W. Up To Date version 12.2, last updated February 25, 2004. Recurrent lesions progress quickly through several stages (prodrome, erythema, papule, vesicle, ulcer, crust, residual swelling, healed). The natural history of recurrent herpes simplex labialis. Spruance S, Stewart J, Rowe N, Mc Koeugh M, Wenerstrom G, Freeman D. London: BMJ Publishing Group, last updated December 2002. This evidence supports early (prodrome or erythema stage) but not late (macule, papule, vesicle, or crusted stage) treatment of HSV 1 with oral acyclovir. Treatment of recurrent herpes simplex labialis with oral acyclovir. Spruance S, Nett R, Marbury T, Wolff R, Johnson J, Spaulding T. High-dose, short-duration, early valacyclovir therapy for episodic treatment of cold sores: results of two randomized, placebo-controlled, multicenter studies. Topical application of 5% acyclovir cream significantly decreases clinician-assessed duration of the episode and duration of patient-reported pain, based on 2 double-blind, multicenter RCTs that used a vehicle control. Acyclovir cream for treatment of herpes simplex labialis: results of two randomized, double-blind, vehicle-controlled multicenter clinical trials. In these trials, 686 and 699 patients self-initiated treatment 5 times a day for 4 days beginning within 1 hour of the onset of a recurrent lesion. Treatment and prevention of herpes simplex virus type 1 infection. Evidence summary Cold sores, or herpes labialis, are caused by HSV. If started at the onset of symptoms (during the prodrome stage), acyclovir (400 mg 5 times daily for 5 days) decreases pain and healing time to loss of crust and valacyclovir (2 g twice daily for 1 day) reduces the lesion duration and time to healing and may prevent lesion development (SOR: A, based on RCTs). However, topical acyclovir 5% cream applied 5 times a day decreases pain and the duration of hard crust (SOR: B, extrapolated from randomized controlled trials [RCTs]). Also known as: Valtrex The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care."I have been getting cold sores ever since I could remember. Carmex, abreva, tea tree oil, and other over the counter cold sore medications with minimal luck. I even used acyclovir, which I thought was the best thing out there until I got valalcyclovir. I felt a raging bump on my upper lip 2 days ago and took 2g about 4hrs after I felt it. After 12hrs, the bump increased in size and I was absolutely devastated, but took another 2g. After 12hrs the bump looked like it is about to burst, but it didn’t, in fact, it shrunk. Took another 2g and after 4hrs the thing is almost gone.
Several medications, including Valtrex, are available to treat cold sores. Some are used topically (on the skin) and others are used orally (by mouth), but the goal is to treat cold sores as early as possible. That's because starting a medication when prodromal symptoms such as burning, tingling, or redness begin will give a person with a cold sore the best chance of either preventing an actual blister from forming or shortening a blister's course once it does appear. While the FDA has approved the use of certain drugs for cold sores, some antiviral drugs aren't specifically FDA-approved for cold sores but have been shown in clinical studies to be effective treatments. Given this, receiving a prescription for an off-label use of one of these drugs may help eliminate or prevent cold sores. Antiviral drugs can have several effects on oral herpes simplex viral infections, including cold sores. These medications can decrease the time that it takes for cold sores to heal and reduce symptoms, especially pain. Cold sores are painful and oozing, and they always seem to appear before that wedding or class reunion. Cold sores are typically caused by type 1 virus (HSV-1). Also called fever blisters, the small, fluid-filled lesions typically form near or on your lips and can cause symptoms such as tingling, itching, or burning. But in some cases, HSV-1 can cause sores on the genitals and type 2 virus (HSV-2) can cause sores on the mouth. But, because they’re caused by a virus, they can be treated with antiviral medications. Valtrex, which contains the active ingredient valacyclovir, can help your cold sores clear up faster. It can also reduce the number of cold sores you get. Read on to learn how Valtrex works and how to use it to treat your cold sores. Cold sores typically start to heal on their own within about four to six days. Although, the first cold sore you get will likely last longer. Most people don’t require treatment for their cold sores, but, in some cases, a doctor may prescribe an antiviral medication such as Valtrex.
This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. To find the most current information, please enter your topic of interest into our search box. 27, 2002 -- Here's good news for cold sore sufferers. Just one day of treatment with a medication called Valtrex makes the unsightly, painful sores disappear faster. A study presented at the American Academy of Dermatology's summer meeting, held in New York this week, outlines results from a large trial of Valtrex. "The findings of these studies are encouraging as they show there may be a convenient and effective way for people with cold sores to treat their outbreaks," says researcher Stephen K. Tyring, MD, Ph D, of the University of Texas Medical Branch at Galveston, in a news release. A one-day oral treatment that shortens the duration of outbreaks has clear advantages over currently available topical treatments, he says. Introduction Recurrent herpes labialis (RHL), or the recurrent expression of herpes simplex virus type 1 (HSV-1), is a commonly occurring viral infection of the mouth and perioral soft tissues. Commonly known as "cold sores" or "fever blisters," RHL typically manifests through reactivation of initial exposure to HSV-1, often triggered by stimuli such as sunlight, stress, menses, or trauma to the affected area. Viral Origin and Pathology of the Cold Sore The most common form of HSV-1 infection is primary gingivostomatitis; however, only about 1% of those exposed to HSV-1 develop clinical symptoms of primary gingivostomatitis. Patients experiencing primary infection may present with fever, malaise, loss of appetite, or multiple intraoral vesicles that burst, leaving painful ulceration. Because of the pain associated with swallowing, children especially may become dehydrated. After ascending the dorsal root ganglion during primary infection, the virus lies dormant in the form of chronic latent infection in trigeminal, facial, vagal, and other various ganglia. Evidence suggests that latent infection also develops in epithelial lip tissue.
Cold Sores acyclovir, Valtrex, valacyclovir, Zovirax, famciclovir, Famvir, benzocaine topical, tetracaine topical, Denavir, Zovirax Cream, Sitavig, More. Mobile Apps The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The #1 Trusted Brand for Herpes & Cold Sore ”Can I use ProsurX with prescription medication like Valacyclovir Valtrex, Acyclovir or Famvir?” Yes, you can.