Cytotec 400 mcg

By: Kin Date of post: 15-Feb-2019
Early Medical Abortion Regimens Using Different Dosages of.

Early Medical Abortion Regimens Using Different Dosages of.

200 mcg orally 4 times a day after meals and at bedtime -Maintenance dose: 100 to 200 mcg orally 4 times a day Comment: Treatment should be taken for the duration of non-steroidal anti-inflammatory drug (NSAID) therapy. Use: Reducing the risk of NSAID-induced gastric ulcers in patients at high risk of complications from gastric ulcers (e.g., patients who are elderly, with concomitant debilitating disease) or at high risk of developing gastric ulceration (e.g., history of gastric ulcer) 200 mcg orally 4 times a day after meals and at bedtime -Maintenance dose: 100 to 200 mcg orally 4 times a day Comment: Treatment should be taken for the duration of non-steroidal anti-inflammatory drug (NSAID) therapy. Use: Reducing the risk of NSAID-induced gastric ulcers in patients at high risk of complications from gastric ulcers (e.g., patients who are elderly, with concomitant debilitating disease) or at high risk of developing gastric ulceration (e.g., history of gastric ulcer) 200 mcg orally 4 times a day after meals and at bedtime -Maintenance dose: 100 to 200 mcg orally 4 times a day Comment: Treatment should be taken for the duration of non-steroidal anti-inflammatory drug (NSAID) therapy. Use: Reducing the risk of NSAID-induced gastric ulcers in patients at high risk of complications from gastric ulcers (e.g., patients who are elderly, with concomitant debilitating disease) or at high risk of developing gastric ulceration (e.g., history of gastric ulcer) American College of Obstetricians and Gynecologists (ACOG) Recommendations: 25 mcg vaginally every 3 to 6 hours -Some patients may require doses of 50 mcg every 6 hours Comments: -The manufacturer states that use outside of the approved indication should be reserved for hospital use only. -Some experts state that this drug is a more efficient method of labor (compared to oxytocin) in patients before 28 weeks' gestation. -Higher doses may be associated with a higher risk of adverse events (e.g., uterine tachysystole with fetal heart rate decelerations). -Use should be avoided during the third trimester or in patients with a history of cesarean delivery or major uterine surgery. To test the effectiveness and acceptability of an outpatient medical abortion protocol with 200 mg mifepristone and 400 mcg sublingual misoprostol at 64–70 days' last menstrual period (LMP) and compare it to the already known efficacy of the 57–63 days' LMP gestational age range. We conducted a prospective, comparative open-label trial in six hospitals and clinics in Ukraine, Georgia, India and Tunisia. We enrolled 714 reproductive age women with pregnancies 57 to 70 days who presented requesting abortion. Medical abortions were managed with the current service delivery protocol (200 mg oral mifepristone followed in 24–48 h by 400 mcg sublingual misoprostol). Data on safety, efficacy and acceptability were collected. The main outcome measure was complete abortion without surgical intervention at any point. Success rates did not differ significantly in the two groups [57–63-day group: 94·8%; 64–70-day group: 91.9%; Relative Risk (RR): 0.79 (0.61–1.04)]. Ongoing pregnancy rates also did not differ significantly (57–63 days: 1.8%; 64–70 days: 2.2%; RR: 1.10 (0.65–1.87)].

A comparison of vaginal misoprostol 800 microg versus <i>400</i> microg for.

A comparison of vaginal misoprostol 800 microg versus 400 microg for.

MINNEAPOLIS — Sublingually administered misoprostol was significantly more effective than the drug given orally after mifepristone for medical abortion in a prospective randomized trial, Sheila Raghavan said at the annual meeting of the Association of Reproductive Health Professionals.“Medical abortion is becoming more popular and is preferred by women because of the ease of administration and convenience,” Ms. Misoprostol typically has been administered orally or vaginally for abortion, although this use is off-label and, in fact, the labeling for misoprostol carries a boxed warning stating that its use by pregnant women can not only cause abortion but also birth defects and uterine rupture. Pharmacokinetic studies have shown higher bioavailability and more rapid absorption when given sublingually. Initial investigations into this route of administration used high doses of sublingual misoprostol and found a high—98%—efficacy rate, but also showed a high rate of side effects. For investigation of whether a lower dose (400 mcg) of misoprostol given sublingually after 200 mg oral mifepristone would be effective, tolerable, and acceptable to women, 480 women who ranged in age from 18 to 46 years who were presenting for termination of intrauterine pregnancy were enrolled in the study. Approximately 55% of the women had had previous abortions. Raghavan, who is program research coordinator at Gynuity Health Projects, a reproductive health research and technical assistance organization in New York City. For example, in one study comparing sublingual and vaginal misoprostol given in a dose of 800 mcg, 54% of women receiving the sublingual drug experienced nausea, compared with 32% of those receiving the drug vaginally (Hum. A total of 240 women were randomized to receive the oral drug, and 240 to receive the sublingual drug, at home 24 hours after receiving 200 mg oral mifepristone in the clinic. Two weeks later they were seen for follow-up assessment, at which time success rates of 98.7% and 94% were seen in the sublingual and oral groups respectively, a difference that statistically favored the sublingual route, Ms. Four cases, all in the oral group, required surgical intervention. Fever and chills occurred more frequently in the sublingual group, with 28% of patients reporting these side effects, compared with 18% in the oral group. The nausea lasted significantly longer in the oral group, however, and more than 80% of women in both groups reported that the side effects were acceptable or very acceptable. A 2011 Cochrane review to compare different methods of second trimester medical termination of pregnancy for their efficacy and side-effects (Wildschut) found: "A range of doses of vaginally administered misoprostol has been used. No randomised trials comparing doses of misoprostol were identified; however low doses of misoprostol appear to be associated with fewer side-effects while moderate doses appear to be more efficient in completing abortion.

<strong>Cytotec</strong> - FDA
Cytotec - FDA

Cytotec oral tablets contain either 100 mcg or 200 mcg of misoprostol. after single doses show a linear relationship with dose over the range of 200-400 mcg. Of misoprostol for second trimester induction at. 14–30 weeks showed that 400 mcg of vaginal misoprostol. 6 hourly provided the optimal regimen, with a shorter.

Cytotec 400 mcg
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