Believe it or not, prednisone can be prescribed for all of the following conditions: allergies, arthritis, lupus, asthma, ulcerative colitis, multiple sclerosis, a sore throat, and even sinus infections. Well, not quite: Prednisone is a corticosteroid, which works to decrease your immune response, as well as turn down inflammation in your body, explains Virginia Boomershine, ambulatory clinical pharmacy regional senior manager for Banner Pharmacy Services. For that reason, it can be used to quell symptoms of a ton of different conditions. However, the med comes with a bunch of seriously annoying side effects. “The likelihood of side effects depends on the dose. You can be prescribed anywhere from 10 to 60 milligrams (mg) a day. A high dose or long-term usage opens you up to more reactions occurring,” says Boomershine. Because of this, you might want to talk to your doctor about taking something else for minor problems. Prednisone and prednisolone are glucocorticoids which reduce inflammation and inhibit immune system responses. They are several times stronger than the stress hormone “cortisol” which is produced naturally in a dog’s adrenal glands and are often used for treating Addison’s disease in which your dog’s glands do not produce enough cortisol on their own. Because they suppress the immune system they are also effective in the treatment of allergies and are sometimes used as a follow-up to epinephrine when dogs have suffered anphylactic shock (a very severe allergic reaction). In terms of antiinflammatory effects, prednisolone is 4x more potent than hydrocortisone. It is not to be confused with methylprednisolone, which is a slightly more powerful variant of the drug. What’s the difference between prednisone and prednisolone? Prednisone is actually a “precursor” to prednisolone.
Prednisone is used for many different autoimmune diseases and inflammatory conditions, including: asthma, COPD, CIDP, rheumatic disorders, allergic disorders, ulcerative colitis and Crohn's disease, adrenocortical insufficiency, hypercalcemia due to cancer, thyroiditis, laryngitis, severe tuberculosis, urticaria (hives), lipid pneumonitis, pericarditis, multiple sclerosis, nephrotic syndrome, sarcoidosis, to relieve the effects of shingles, lupus, myasthenia gravis, poison oak exposure, Ménière's disease, autoimmune hepatitis, giant-cell arteritis, the Herxheimer reaction that is common during the treatment of syphilis, Duchenne muscular dystrophy, uveitis, and as part of a drug regimen to prevent rejection after organ transplant. It is important in the treatment of acute lymphoblastic leukemia, non-Hodgkin lymphomas, Hodgkin's lymphoma, multiple myeloma, and other hormone-sensitive tumors, in combination with other anticancer drugs. Prednisone can be used in the treatment of decompensated heart failure to increase renal responsiveness to diuretics, especially in heart failure patients with refractory diuretic resistance with large dose of loop diuretics. In terms of the mechanism of action for this purpose: prednisone, a glucocorticoid, can improve renal responsiveness to atrial natriuretic peptide by increasing the density of natriuretic peptide receptor type A in the renal inner medullary collecting duct, inducing a potent diuresis. Short-term side effects, as with all glucocorticoids, include high blood glucose levels (especially in patients with diabetes mellitus or on other medications that increase blood glucose, such as tacrolimus) and mineralocorticoid effects such as fluid retention. The mineralocorticoid effects of prednisone are minor, which is why it is not used in the management of adrenal insufficiency, unless a more potent mineralocorticoid is administered concomitantly. It can also cause depression or depressive symptoms and anxiety in some individuals. Prednisone is a corticosteroid used to treat a variety of diseases like irritable bowel syndrome, adrenal cortex insufficiency, rheumatoid arthritis, skin rashes, thyroid gland diseases, ulcerative colitis, allergies, psoriasis, blood disorders, multiple sclerosis, etc. As there are numerous benefits, it is one of the most popular and widely used drugs. However, there are also several side effects associated with this drug. Headache, dizziness, abdominal pain, indigestion, etc., are some of the common side effects of corticosteroids and antibiotics. Steroid induced osteoporosis is one of the most significant side effects of prednisone. Steroids decrease the calcium absorption capacity of the body which results in bone fractures and diseases like osteoporosis. is typically observed if this drug is taken for an extended period.
Prednisone passes into breast milk. Breastfeeding while using prednisone is not recommended. Our Prednisone Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Preferably this should not exceed 10 mg per day. Use of the lowest effective dose will tend to minimise side-effects. The incidence of side-effects increases with.