Prednisone bone damage

By: lefunty Date of post: 15-Feb-2019
Effects of Low‐Dose <b>Prednisone</b> on <b>Bone</b> Metabolism - Ton - 2005.

Effects of Low‐Dose Prednisone on Bone Metabolism - Ton - 2005.

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<strong>Prednisone</strong> Uses, Dosage, Side Effects, Warnings -

Prednisone Uses, Dosage, Side Effects, Warnings -

Corticosteroids can cause fractures by reducing bone formation and the viability of osteoblasts and osteocytes. The heightened fracture risk is dose dependent and occurs within months of starting therapy. Daily doses of more than 2.5 mg prednisolone or equivalent are associated with a higher fracture risk. Randomised studies reveal adverse skeletal effects with daily doses as low as 5 mg. After treatment stops, the fracture risk rapidly falls towards baseline unless the patient was taking long-term therapy. Patients who start corticosteroid therapy should routinely receive calcium and vitamin D supplementation. Those with a higher risk of fracture should also be offered a bisphosphonate. Glucocorticoids are produced naturally by the body as cortisol or cortisone, and are necessary for normal metabolism, growth and responding to physical stresses such as infection, injury and inflammation. However, high levels of glucocorticoids (both natural and synthetic) are associated with reduced activity of the bone-forming cells and increased activity of the cells that break down bone, which may result in bone loss. prednisone, dexamethasone) are widely used in a variety of conditions because they are very effective anti-inflammatory drugs. Hydrocortisone and cortisone acetate are used to treat individuals who are deficient in cortisone. Glucocorticoids are taken in a number of different ways. Bone damage more commonly results from the long-term use of glucocorticoid pills, such as prednisone, when taken at a dose of 7.5 mg (or more) daily for 3 (or more) months (these do not have to be consecutive) in the previous year. Glucocorticoid joint injections, inhalers, skin creams or eye drops have not been shown to increase the risk of osteoporosis. If treatment with glucocorticoid pills such as prednisone is required, bone health should be carefully monitored.

Corticosteroid-induced osteoporosis and fractures Australian Prescriber
Corticosteroid-induced osteoporosis and fractures Australian Prescriber

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Prednisone bone damage
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