Department of Early Diagnosis of Arthritis, Institute of Rheumatology, Spartanska 1, 02-627 Warsaw, Poland Received 20 January 2012; Revised 13 July 2012; Accepted 16 July 2012Academic Editor: Kazuhito Asano Copyright © 2012 Brygida Kwiatkowska and Maria Maślińska. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Macrolides are a group of antibiotics with a distinctive macrocyclic lactone ring combined with sugars (cladinose, desosamine). The action of macrolides is to block protein synthesis by binding to the subunit of 50S ribosome of bacteria. Prototype macrolide was erythromycin, which came into clinical practice in the 50s of the 20th century. Its antimicrobial spectrum covers the scope of the penicillins but is extended to the impact of atypical bacteria. In the 90s more drugs of this group were synthesized—they have less severe side effects than erythromycin, extended spectrum of Gram-negative bacteria. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Azithromycin, an antibiotic, may be beneficial at reducing the symptoms and severity of the disease. Listing a study does not mean it has been evaluated by the U. This study will analyze previously collected study data to evaluate the anti-inflammatory properties of azithromycin and determine how azithromycin affects the frequency and severity of COPD exacerbations. Chronic obstructive pulmonary disease (COPD) is a chronic lung disease. COPD is a disease in which the lung airways are partly damaged and obstructed, making it difficult to breathe. The most common cause is cigarette smoking, but breathing in other types of lung irritants, including pollution, dust, and chemicals, over a long period of time may also contribute to COPD. It is the fourth leading cause of death in the United States. Symptoms include coughing, excess mucus production, shortness of breath, wheezing, and chest tightness.
Nov 1, 2012. 2012. 2. As of 1 December, 2012, a 250 mg azithromycin tablet. medicine would be used for its anti-inflammatory properties, that it would be. Jornal Brasileiro de Pneumologia. Anti-inflammatory effects of macrolides in childhood. Azithromycin inhibits IL-5 production of T helper type 2 cells from.