Reproduction studies performed in rabbits at doses up to approximately 3 times the oral maximum recommended daily human dose (MRDHD) of clonidine hydrochloride produced no evidence of a teratogenic or embryotoxic potential in rabbits. In rats, however, doses as low as 1/3 the oral MRDHD (1/15 the MRDHD on a mg/m basis) of clonidine were associated with increased resorptions in a study in which dams were treated continuously from 2 months prior to mating. Increased resorptions were not associated with treatment at the same time or at higher dose levels (up to 3 times the oral MRDHD) when the dams were treated on gestation days 6-15. Increases in resorption were observed at much higher dose levels (40 times the oral MRDHD on a mg/kg basis; 4 to 8 times the MRDHD on a mg/m basis) in mice and rats treated on gestation days 1-14 (lowest dose employed in the study was 500 mcg/kg). No adequate well-controlled studies have been conducted in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Skin burns have been reported at the patch site in several patients wearing an aluminized transdermal system during a magnetic resonance imaging scan (MRI). Clonidine isn’t the go-to drug for attention deficit hyperactivity disorder (ADHD). Generally, stimulants such as methylphenidate (Ritalin) are used. However, stimulants may not be appropriate for people with ADHD who also have sleep disorders or other conditions that stimulants may negatively affect. For these people, clonidine may be a better option. Clonidine is included in a class of drugs called alpha-agonist hypotensive agents. Food and Drug Administration (FDA) to treat high blood pressure. These drugs relax blood vessels to help increase your blood flow. Later, in 2010, clonidine was also FDA-approved to treat ADHD in children. Exactly how this drug helps relieve the symptoms of ADHD is not known.
It causes the dilation of the blood vessels thus, reducing the pressure with which the blood flows. It is used not only for controlling high blood pressure but also for providing a preventive treatment of migraine headache, providing relief from certain types of pain and treating anxiety. It is also used to treat Attention deficit hyperactivity disorder (ADHD). Stopping the use of alcohol and smoking an individual taking it.3) An individual may feel drowsy. Hence, one should be very careful while doing activities that require focus and alertness. Hence, you should avoid doing activities like, driving or operating machinery, if you feel drowsy.4) The eyes may become dry. Moreover, a burning sensation and itching in the eyes can be caused.5) There is dryness of the mouth as the saliva secretion decreases.6) There is a decline in interest of eating as one of the side effects of clonidine 0.1 mg.7) Nausea may be caused.8) Moreover, there may be vomiting also.9) An individual taking it may feel weak and tired.10) There may be swelling of the feet and lower legs.11) Pain in the abdomen can be caused as one of the side effects of clonidine 0.1 mg.12) It may also cause impotence in men.13) Blurred vision .14) Tremors can be caused.15) Allergic reaction like, rashes and hives may be caused.16) Joint pain may be caused.17) One may have nightmares as a side effect of taking it. Stopping its use may produce withdrawal anxiety, agitated behavior, pain in the chest, trembling of hands, difficulty in falling asleep, nausea, vomiting and headache. • Before use, dilute clonidine hydrochloride 500-μg/m L strength product in appropriate solution. • Epidural form (clonidine hydrochloride) isn't recommended for obstetric, postpartum, or perioperative pain management. In these cases, risk of hemodynamic instability may be unacceptable, except in rare patients for whom potential benefits may outweigh possible risks. Stimulates alpha-adrenergic receptors in CNS, decreasing sympathetic outflow, inhibiting vasoconstriction, and ultimately reducing blood pressure. Also prevents transmission of pain impulses by inhibiting pain pathway signals in brain. (morning and bedtime) alone or with other anti-hypertensives; increase in increments of 0.1 mg/day q week until desired response occurs. Solution for epidural injection: 100 mcg/ml in 10-ml vials, 500 mcg/ml in 10-ml vials Tablets: 100 mcg (0.1 mg), 200 mcg (0.2 mg), 300 mcg (0.3 mg) Transdermal systems: 2.5 mg total released as 0.1 mg/24 hours (TTS 1), 5 mg total released as 0.2 mg/24 hours (TTS 2), 7.5 mg total released as 0.3 mg/24 hours (TTS 3) Mild to moderate hypertension Adults: 0.1 mg P. Or, one transdermal system applied once q 7 days to hairless area of intact skin on upper outer arm or chest. • Hypersensitivity to drug • Hypersensitivity to components of adhesive layer (transdermal form) • Infection at epidural injection site, bleeding problems (epidural use) • Concurrent anticoagulant therapy CNS: drowsiness, depression, dizziness, nervousness, nightmares CV: hypotension (especially with epidural use), palpitations, bradycardia GI: nausea, vomiting, constipation, dry mouth GU: urinary retention, nocturia, erectile dysfunction Metabolic: sodium retention Skin: rash, sweating, pruritus, dermatitis Other: weight gain, withdrawal phenomenon Drug-drug.
Clonidine belongs to a class of drugs called central alpha-adrenergic agonists. In the United States, clonidine tablets are sold under the brand name Catapres and clonidine skin patches are sold under the brand name Catapres-TTS. There is also an injectable form that is administered directly into the spinal cord for the treatment of postoperative pain. Clonidine tablets and patches are approved by the United States Food and Drug Administration (FDA) for the treatment of high blood pressure. However, clonidine has been found to be useful in the treatment of alcohol, opiate, and nicotine withdrawal syndromes, attention-deficit/hyperactivity disorder (ADHD), and Tourette's syndrome, one of the tic disorders . Clonidine was synthesized in 1960s and was initially tested as a nasal decongestant. In the United States, clonidine was first used to treat hypertension although it has also been investigated for treatment of different neuropsychiatric disorders. Clonidine works on specific nerve cells in the brain that are responsible for lowering blood pressure, slowing heart rate, and decreasing the body's reaction to the withdrawal of chemicals like alcohol, opiates, cocaine, and nicotine. Clonidine is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk for heart attacks. These problems may be less likely to occur if the blood pressure is controlled. Clonidine belongs to the class of medicines called antihypertensives.
Clonidine lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels to relax and your heart to beat more. For treatment of high blood pressure, the usual starting dose of clonidine is 0.1 mg twice daily, taken in the morning and at bedtime. After 2 to 4 weeks, your.